Vepris macrophylla Essential Oil Produces Notable Antiproliferative Activity and Morphological Alterations in Human Breast Adenocarcinoma Cells

Medicinal plants contain numerous bioactive molecules that synergistically provide therapeutic benefits. We have devoted our attention to various EOs without toxicity normal cells, studying their activities against human cancer cells. In particular, we studied the cytotoxicity of Vepris macrophylla (Baker) I. Verd. EO. V. is an evergreen tree Madagascar where much appreciated as a source traditional remedies. Its major volatile components are citral, i.e., mixture neral and geranial, citronellol myrcene. The antiproliferative EO were breast adenocarcinoma cell line SKBR3. Cellular metabolism was analyzed by MTT assay at different concentrations times incubation (24, 48 72 h). Moreover, morphological ultrastructural analyses performed study its effects demonstrating ability EO, stored inside intracellular vesicles, damage both plasma membranes disorganize cytoskeleton protein actin filaments.